Information about the transmission of documents see Guideline: electronic Release Regulation EEVO (L_Z45).
ASMF holders who are submitting an ASMF for more than one MAA (=Marketing Authorization Application) should submit their ASMF and its changes in the latest version only once. For the correct technical use and preservation of the eCTD-lifecycle of this standalone dossier it is mandatory that every new Letter of Access in relation to a specific MAA should be submitted in an updated eCTD sequence as well as changes to the ASMF.
For example 1: An ASMF has been submitted to the NCA (=National competent authority) with eCTD-sequence 0000 for medicinal product A. In any later MAA referencing to this ASMF, the ASMF holder is only required to submit the new Letter of Access for medicinal product B in an subsequent eCTD-sequence (e.g. eCTD-sequence 0001, 0002, …).